I Created Disco is the debut studio album by Scottish recording artist Calvin Harris, released on 15 June 2007 by Columbia Records. It was preceded by the singles "Acceptable in the 80s" and "The Girls", which reached numbers ten and three on the UK Singles Chart, respectively.
The album debuted at number eight on the UK Albums Chart with first-week sales of 16,121 copies. On 23 May 2008, it was certified gold by the British Phonographic Industry (BPI).I Created Disco had sold 223,845 copies in the United Kingdom by November 2014.
Writing and recording for I Created Disco started in 2006 when Harris moved back to his hometown of Dumfries, Scotland, after living in London for two years. All recording and producing for the album took place on an Amiga computer with audio tracker OctaMED in Harris's home studio, called Calvinharrisbeats Studio. All fourteen tracks on the album were written, produced and performed solely by Harris.
Preceding the release of the album, Columbia released two singles, "Acceptable in the 80s" and "The Girls", and Harris and his band supported both Faithless and Groove Armada on their live arena tours in the second quarter of 2007. The album cover was also used to promote the fourth generation iPod Nano in yellow.
Vegas is a one-off collaborative album between British solo-artist Terry Hall - formerly of the 2 Tone and ska revival band The Specials - with Dave Stewart formerly of Eurythmics. The duo working with Eurythmics assistants engineer and drummer Olle Romo and engineer Manu Guiot recorded under the group name Vegas. Vegas includes the singles "Possessed", "She" and "Walk into the Wind". Of the three only "Possessed" charted in the UK Top 40. Receiving positive reviews the album was released on CD, Cassette and vinyl LP by the major record label RCA/BMG in October 1992, but failed to chart. The album has since been deleted.
The album was written by Hall and Stewart with the exception of the musical standard "She". No performer credits are provided, Allmusic speculates that Vegas is almost certainly a Dave Stewart production. Dave Stewart likely was responsible for the lion's share of the musical backing with assistance from Romo and Guiot and Hall contributing his vocal.
Following the album's commercial failure the group split. Hall subsequently launched a solo-career, releasing Home in 1994. Stewart also returned to solo-work, releasing Greetings from the Gutter in 1994. The pair re-united in 1997 to support Bob Dylan during his Never Ending Tour for a pair of concerts in Japan.
"Vegas" is the fourth single by English Britpop band Sleeper, written by the band's vocalist and guitarist Louise Wener. It was the fourth and final single to be released from their debut album Smart in March 1994 (see 1994 in British music). The single peaked at #33 on the UK Singles Chart.
The single version, also used in the video, is a completely re-recorded version of the song originally featured on the album. This version features saxophone credited to Morgan C. Hoax- an anagram of Graham Coxon from Blur who recorded his contribution after Sleeper supported Blur on tour.
Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular switches and are vital for effective signal transduction. There are two isoforms of the Rap1 protein, each encoded by a separate gene, RAP1A and RAP1B. Rap1 belongs to Ras-related protein family.
GTPases are inactive when in their GDP-bound form, and become active when they bind to GTP. GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs) regulate small GTPases, with GAPs promoting the GDP-bound (inactive) form, and GEFs promoting the GTP-bound (active) form. When bound to GTP, small GTPases regulate myriad cellular processes. These proteins are divided into families depending on their protein structure, and the most well studied is the Ras superfamily, of which Rap1 is a member. Whereas Ras is known for its role in cell proliferation and survival, Rap1 is predominantly involved in cell adhesion and cell junction formation. Ras and Rap are regulated by different sets of guanine nucleotide exchange factors and GTPase-activating proteins, thus providing one level of specificity.
RAP6 is the abbreviation for Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. RAP6 was discovered by Alejandro Barbieri and his group of researchers (Christine Hunker, Adriana Galvis, Ivan Kruk, Hugo Giambini, Lina Torres and Maria Luisa Veisaga) working at Florida International University.
This novel human protein has been reported to be involved in membrane trafficking. It has been shown that RAP6 has a guanine nucleotide exchange factor (GEF) activity specific to Rab5 and a GTPase activating protein (GAP) activity specific to RAS.
The original GeneBank Identifications (GIs) have been published in the NCBI Nucleotide databases with GIs 77176718 and 77176720. Since then, many names have been coined to the validated protein such as RabGEF1, GeneID: 27342. RAP6 belongs to the family of the GAPVD1, GeneID: 26130